IPC-POC PMPA

IPC-POC PMPA is an acyclic phosphonate ester impurity arising from the synthetic pathway of tenofovir disoproxil fumarate. It features a 9-(2-phosphonylmethoxypropyl)adenine core with a terminal hydroxyl group on the propyl side chain, differing structurally from the parent drug by the absence of one isopropyl ester moiety. This compound originates as a partial hydrolysis byproduct during the phosphorylation step of PMPA synthesis, retaining a monophosphonate intermediate. It functions as a critical HPLC reference standard for quantifying process-related impurities in tenofovir API batches.