isoproxil Tenofovir

Isoproxil Tenofovir is a prodrug derivative of tenofovir, featuring an ester linkage between the isoproxil moiety and the tenofovir phosphate backbone. The compound incorporates a 1-(2-hydroxyethoxy)methyl group at the 5’-position of the deoxyribose sugar, with the isoproxil ester (2-[(2-methoxyethyl)amino]propanoyl) attached via an ethylene glycol spacer. This structural modification enhances lipophilicity and intestinal absorption compared to the parent drug. It undergoes enzymatic hydrolysis in vivo to release active tenofovir. This compound serves as an HPLC reference standard for quantifying prodrug-related impurities in tenofovir alafenamide synthesis.