Lansoprazole Impurity (M+467)

Lansoprazole Impurity (M+467) is a structurally related degradation byproduct arising from oxidative modification of the parent benzimidazole core, featuring an additional sulfonyl (–SO2–) bridge and a pyridine-linked methylsulfonyl substituent. This impurity retains the 3-(3,4-dimethoxybenzoyl)thiazole moiety but exhibits a unique mass shift due to sulfur oxidation and methylation. It serves as a critical HPLC reference standard for quantifying oxidative degradation pathways in lansoprazole formulations.