LEDIPASVIR CHIRAL IMPURITY 6 [(1R,3R,4S) LedipasvirIntermediate]

LEDIPASVIR CHIRAL IMPURITY 6 [(1R,3R,4S)] is a stereoisomeric derivative of the antiviral agent ledipasvir, characterized by a (1R,3R,4S) configuration at its cyclopropylmethyl-substituted piperazine core. This impurity arises from partial inversion at the chiral centers during asymmetric synthesis, resulting in a non-identical mirror image of the parent drug's (1S,3R,4S) configuration. The compound retains the thiophene-2-ylmethyl and 4-aminopiperidine-1-yl moieties critical for protease inhibition but exhibits altered stereochemical interactions. It serves as an HPLC reference standard for enantiomeric purity analysis in ledipasvir API manufacturing.