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Lercanidipine Dimethyl ester impurity oxalate salt

Lercanidipine Dimethyl ester impurity oxalate salt is a synthetic byproduct derived from the esterification of lercanidipine's carboxylic acid moiety with methanol, forming two methyl ester linkages. The compound retains the dihydropyridine core and 2-nitrophenyl substituent of the parent drug but features modified ester functionality, altering its solubility and chromatographic behavior. The oxalate salt form stabilizes the molecule through ionic interactions. This impurity arises during API synthesis due to incomplete acylation or hydrolysis steps. It serves as a critical HPLC reference standard for quantifying process-related impurities in lercanidipine formulations.

On Request
Molecular Formula C23H29N3O10
Molecular Weight 507.5000
CAS Number 957214-95-8 ✓ Verified
PubChem CID 77612573 ↗
Purity N/A
Product Type API Impurity
Parent Drug Lercanidipine
Lead Time On Request
IUPAC Name 3-O-methyl 5-O-[2-methyl-1-(methylamino)propan-2-yl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;oxalic acid

📝 Synonyms

957214-95-8 3-methyl 5-(2-methyl-1-(methylamino)propan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate oxalic salt 3-methyl 5-[2-methyl-1-(methylamino)propan-2-yl]-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate oxalic salt RefChem:503318 695-848-7 N-Des(3,3-Diphenylpropyl) Lercanidipine Oxalate C3Z4S5XA3P 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[1,1-dimethyl-2-(methylamino)ethyl] 5-methyl ester, ethanedioate 3-Methyl 5-(2-Nethyl-1-(methylamino)propan-2-yl) 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Oxalate Salt; [R,S]-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid, N-methyl-N-(2-hydroxy-2-methyl)propylamide Methyl Ester Oxalate Salt;

🔬 Chemical Identifiers

CC1=C(C(C(=C(N1)C)C(=O)OC(C)(C)CNC)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OC.C(=O)(C(=O)O)O
InChI=1S/C21H27N3O6.C2H2O4/c1-12-16(19(25)29-6)18(14-8-7-9-15(10-14)24(27)28)17(13(2)23-12)20(26)30-21(3,4)11-22-5;3-1(4)2(5)6/h7-10,18,22-23H,11H2,1-6H3;(H,3,4)(H,5,6)
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