Linagliptin

Linagliptin is a DPP-4 inhibitor featuring a pyrazine-tetrahydropyridine core fused to a naphthalene substituent via a sulfonamide linkage. The molecule incorporates a 2-oxo-1,2-dihydropyrimidine-5-carboxamide moiety and a cyclopropylmethyl group at the tetrahydropyridine ring. Its structure exhibits a rigid, planar scaffold with hydrogen-bonding capacity from the amide and sulfonamide groups. As the parent drug itself, it retains full pharmacophoric integrity. This compound serves as an HPLC reference standard for quantitative analysis of DPP-4 inhibitor formulations.