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Loratadine N-oxide

Loratadine N-oxide is a metabolite of loratadine, distinguished by the presence of an N-oxide functional group. This modification introduces a polar, electron-withdrawing moiety, altering its chemical properties. Its structure retains the tricyclic core and chlorophenyl substituent of the parent compound. It serves as a specific degradation byproduct reference standard.

On Request
Molecular Formula C22H23ClN2O3
Molecular Weight 398.9000
CAS Number 165739-62-8 ✓ Verified
PubChem CID 29982763 ↗
Purity N/A
Product Type API Impurity
Parent Drug Loratadine
Lead Time On Request
IUPAC Name ethyl 4-(13-chloro-4-oxido-4-azoniatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate

📝 Synonyms

Loratadine N-Oxide 165739-62-8 Sch-38554 ZZ5M934ECV RefChem:1088557 4-(8-Chloro-5,6-dihydro-1-oxido-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester CHEMBL4649329 ethyl 4-(13-chloro-4-oxido-4-azoniatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate Loratadine Impurity 11 Sch 38554

🔬 Chemical Identifiers

CCOC(=O)N1CCC(=C2C3=C(CCC4=C2[N+](=CC=C4)[O-])C=C(C=C3)Cl)CC1
InChI=1S/C22H23ClN2O3/c1-2-28-22(26)24-12-9-15(10-13-24)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-25(27)21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
AEYRDESTWAYZTA-UHFFFAOYSA-N

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