Lorcaserin sulfate TEA salt

Lorcaserin sulfate TEA salt is a pharmaceutically relevant impurity derived from the serotonin 5-HT2C receptor agonist lorcaserin. It features a phthalazine core substituted with a 3-(trifluoromethyl)phenyl group, with a sulfonate moiety (-OSO3^-) conjugated to the molecule's nitrogenous heterocycle. The triethanolamine (TEA) counterion stabilizes the sulfate group through ionic interaction, forming a crystalline salt. This compound arises as a byproduct during lorcaserin synthesis via sulfation reactions or degradation pathways involving acidic conditions. Its distinct sulfonate-TEA linkage differentiates it from the parent drug, enabling use as an HPLC reference standard for impurity profiling in quality control.