ABC00890MD

Loxapine-N-oxide

Loxapine-N-oxide is a structurally related impurity derived from the dibenzazepine core of Loxapine, featuring an N-oxide functional group at the heterocyclic nitrogen. This oxidation product retains the chloro substituent at the benzene ring and exhibits altered electronic properties due to the electron-withdrawing nature of the N-oxide. The compound arises as a synthetic byproduct during oxidative processes or degradation pathways of the parent API. It serves as an HPLC reference standard for quantifying impurity profiles in Loxapine formulations.

On Request
Molecular Formula C18H18ClN3O2
Molecular Weight 343.8000
CAS Number 25967-34-4 ✓ Verified
PubChem CID 91810511 ↗
Purity N/A
Product Type API Impurity
Parent Drug Loxapine
Lead Time On Request
IUPAC Name 8-chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)benzo[b][1,4]benzoxazepine
Official Reference Standards
Std Catalog # Quantity Price
USP 1370699 ↗ 25 mg USD 784.00

📝 Synonyms

Loxapine N-oxide 25967-34-4 Cloxazepine N-oxide UNII-85EE9A1E8B 85EE9A1E8B 8-chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)benzo[b][1,4]benzoxazepine Dibenz(b,f)(1,4)oxazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-, N-oxide Dibenz(b,f)(1,4)oxazepine, 2-chloro-11-(4-methyl-4-oxido-1-piperazinyl)- Dibenz[b,f][1,4]oxazepine, 2-chloro-11-(4-methyl-4-oxido-1-piperazinyl)-; Dibenz[b,f][1,4]oxazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-, N-oxide (8CI); Cloxazepine N-oxide; Loxapine N-oxide ABA96734

🔬 Chemical Identifiers

C[N+]1(CCN(CC1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl)[O-]
InChI=1S/C18H18ClN3O2/c1-22(23)10-8-21(9-11-22)18-14-12-13(19)6-7-16(14)24-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3
QUSWANHLDLADDR-UHFFFAOYSA-N

Related Products