Maravirov MAI-II(free alcohol)

Maravirov MAI-II (free alcohol) is a process-related impurity derived from the antiretroviral drug Maravirov, characterized by the absence of esterification at the terminal hydroxyl group present in the parent compound. Its structure retains the cyclopropylmethylcarbamoyl core but features a free primary alcohol functionality, which significantly impacts its polarity and chromatographic retention. This impurity arises during synthetic steps involving hydrolysis or incomplete acylation. It functions as an HPLC reference standard for quantifying residual impurities in Maravirov drug substance manufacturing.