Maravirov MAI-III(Aldehyde)

Maravirov MAI-III(Aldehyde) is a structurally related oxidation derivative of the parent antiretroviral agent Maraviroc, characterized by the introduction of an electrophilic aldehyde functional group at the terminal cyclopropylmethyl side chain. This impurity arises via oxidative degradation of the cyclopropylmethylene moiety, resulting in a conjugated enal derivative with altered lipophilicity. The aldehyde substituent introduces a reactive electrophilic center, enhancing susceptibility to nucleophilic attack during synthetic purification. This compound serves as a critical HPLC reference standard for quantification of oxidative degradation pathways in Maraviroc drug substance stability studies.