Maravirov R- isomer)

The (R)-isomer of Maravirov is a chiral impurity arising from the enantioselective synthesis of the parent antiretroviral agent. It retains the core 5-(cyclopropylmethyl)-4-chloro-2,6-dimethylpyrimidin-5-yl sulfonamide scaffold but exhibits inverted stereochemistry at the cyclopropylmethyl chiral center relative to the pharmacologically active (S)-enantiomer. This non-therapeutic enantiomer co-purifies during racemic resolution processes and serves as a critical HPLC reference standard for enantiomeric purity quantification in API batches.