Memantine Lactose Adduct

Memantine Lactose Adduct is a non-covalent complex formed via hydrogen bonding between the amino group of memantine and hydroxyl moieties of lactose, resulting in a crystalline solid with altered physicochemical properties compared to the parent drug. This adduct exhibits a 1:1 stoichiometric ratio, stabilized by intermolecular interactions, and is commonly encountered during API formulation processes involving lactose as an excipient. It serves as a critical HPLC reference standard for quantifying lactose-associated impurity profiles in memantine-containing pharmaceuticals.