Mirabegron impurity 6

This compound, 4-(2-{[(2R)-2-hydroxy-2-phenylethyl](methyl)amino}ethyl)aniline, is an API impurity structurally related to Mirabegron, lacking the 2-aminothiazol-4-yl-acetamide moiety. It features a primary aniline functionality at one terminus of a 4-substituted phenyl ring, which is linked via an ethylene bridge to a tertiary N-methylated amine. The tertiary amine is further substituted with a (2R)-2-hydroxy-2-phenylethyl group, incorporating a chiral hydroxylated benzylic center. This impurity represents a N-methylated des-thiazolyl-acetamide derivative of Mirabegron. It serves as a crucial reference standard for chromatographic purity assays of Mirabegron.