ABC00962ND

Mometason Furoate Impurity G

Mometason Furoate Impurity G is a chlorinated synthetic byproduct derived from the parent corticosteroid via oxidation of the 11ฮฒ-hydroxyl group to a keto functionality, coupled with C-16ฮฑ chlorination. Its structure retains the 9ฮฑ-fluoro and 17ฮฑ-propynyl moieties of mometasone furoate but features a 21-furoate ester linkage and a 16ฮฑ-chloro substitution, distinguishing it as a key degradation intermediate. This compound serves as an HPLC reference standard for quantifying process-related impurities in API batches.

On Request
Molecular Formula C22H28Cl2O4
Molecular Weight 427.4000
CAS Number 105102-22-5 โœ“ Verified
PubChem CID 441335 โ†—
Purity N/A
Product Type API Impurity
Parent Drug Mometason
Lead Time On Request
IUPAC Name (8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Official Reference Standards
Std Catalog # Quantity Price
USP 1A19460 โ†— 25 mg USD 626.00

๐Ÿ“ Synonyms

Mometasone 105102-22-5 (+)-Mometasone Mometasona Mometasonum (8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one 8HR4QJ6DW8 CHEBI:6970 9,21-dichloro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione DTXSID10872412

๐Ÿ”ฌ Chemical Identifiers

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CCl)O)C)O)Cl)C
InChI=1S/C22H28Cl2O4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-17,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
QLIIKPVHVRXHRI-CXSFZGCWSA-N

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