ABC00968ZB

Mometasone Furoate EP Impurity C

Mometasone Furoate EP Impurity C is a synthetic byproduct arising from incomplete esterification during parent drug production. It retains the 9ฮฑ-fluoro-11ฮฒ-hydroxy-17ฮฑ-methyl-17-propynyl steroid core but lacks the furoate moiety at the 17ฮฒ-hydroxyl position, presenting a free hydroxyl group instead. This structural divergence results in reduced lipophilicity compared to the parent compound. The impurity serves as a critical HPLC reference standard for quantifying residual esterification intermediates in API batches.

On Request
Molecular Formula C27H29ClO6
Molecular Weight 485.0000
CAS Number 1305334-31-9 โœ“ Verified
PubChem CID 129011920 โ†—
Purity N/A
Product Type API Impurity
Parent Drug Mometasone
Lead Time On Request
IUPAC Name [(8S,9S,10R,13S,14S,16R,17R)-17-(2-chloroacetyl)-10,13,16-trimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] furan-2-carboxylate
Official Reference Standards
Std Catalog # Quantity Price
USP 1445462 โ†— 15 mg USD 950.00

๐Ÿ“ Synonyms

1305334-31-9 58W685J9DX 9-Dechloro-11-oxo mometasone furoate Mometasone furoate impurity C [EP] 21-chloro-16alpha-methyl-3,11,20-trioxopregna-1,4-dien-17-yl furan-2-carboxylate (16alpha)-21-Chloro-17-((2-furanylcarbonyl)oxy)-16-methylpregna-1,4-diene-3,11,20-trione MOMETASONE FUROATE IMPURITY C [EP IMPURITY] Pregna-1,4-diene-3,11,20-trione, 21-chloro-17-((2-furanylcarbonyl)oxy)-16-methyl-, (16alpha)- (16alpha)-21-Chloro-17-[(2-furanylcarbonyl)oxy]-16-methylpregna-1,4-diene-3,11,20-trione 21-CHLORO-16.ALPHA.-METHYL-3,11,20-TRIOXOPREGNA-1,4-DIEN-17-YL FURAN-2-CARBOXYLATE

๐Ÿ”ฌ Chemical Identifiers

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@H]3C(=O)C[C@@]2([C@]1(C(=O)CCl)OC(=O)C5=CC=CO5)C)C
InChI=1S/C27H29ClO6/c1-15-11-19-18-7-6-16-12-17(29)8-9-25(16,2)23(18)20(30)13-26(19,3)27(15,22(31)14-28)34-24(32)21-5-4-10-33-21/h4-5,8-10,12,15,18-19,23H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,23-,25+,26+,27+/m1/s1
UDJQOKVZFMMKGS-HAZRNBFISA-N

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