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Mometasone Furoate EP Impurity F

Mometasone Furoate EP Impurity F is a hydroxylated derivative of the parent corticosteroid, featuring a furan-2-ylmethyl ester moiety and two chlorine substituents at C-6 and C-9 positions. The compound exhibits a 11ฮฒ-hydroxy group and a 16ฮฑ-methyl-3-oxo-ฮ”1-androstane skeleton, differing from mometasone by a hydroxyl substitution at C-21. This impurity arises via oxidative degradation pathways during synthesis, introducing a labile hydroxyl group that enhances polarity. It serves as an HPLC reference standard for quantifying process-related impurities in mometasone formulations.

On Request
Molecular Formula C27H28Cl2O7
Molecular Weight 535.4000
CAS Number 1305334-30-8 โœ“ Verified
PubChem CID 129011919 โ†—
Purity N/A
Product Type API Impurity
Parent Drug Mometasone
Lead Time On Request
IUPAC Name [(8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3,6-dioxo-8,11,12,14,15,16-hexahydro-7H-cyclopenta[a]phenanthren-17-yl] furan-2-carboxylate

๐Ÿ“ Synonyms

1305334-30-8 6-Oxo Mometasone Furoate Mometasone Furoate Impurity F HQ9B6K29E6 Mometasone furoate impurity F [EP] 9,21-Dichloro-11beta-hydroxy-16alpha-methyl-3,6,20-trioxopregna-1,4-dien-17-yl furan-2-carboxylate MOMETASONE FUROATE IMPURITY F [EP IMPURITY] (11.BETA.,16.ALPHA.)-9,21-DICHLORO-17-((2-FURANYLCARBONYL)OXY)-11-HYDROXY-16-METHYLPREGNA-1,4-DIENE-3,6,20-TRIONE (11beta,16alpha)-9,21-Dichloro-17-((2-furanylcarbonyl)oxy)-11-hydroxy-16-methylpregna-1,4-diene-3,6,20-trione 9,21-DICHLORO-11.BETA.-HYDROXY-16.ALPHA.-METHYL-3,6,20-TRIOXOPREGNA-1,4-DIEN-17-YL FURAN-2-CARBOXYLATE

๐Ÿ”ฌ Chemical Identifiers

C[C@@H]1C[C@H]2[C@@H]3CC(=O)C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CCl)OC(=O)C5=CC=CO5)C)O)Cl)C
InChI=1S/C27H28Cl2O7/c1-14-9-16-17-11-19(31)18-10-15(30)6-7-24(18,2)26(17,29)21(32)12-25(16,3)27(14,22(33)13-28)36-23(34)20-5-4-8-35-20/h4-8,10,14,16-17,21,32H,9,11-13H2,1-3H3/t14-,16+,17+,21+,24+,25+,26+,27+/m1/s1
XXMUYUVNHWPWLS-KORTYEGJSA-N

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