Mono acetyl Dapagliflozin

Mono acetyl Dapagliflozin is a structurally modified derivative of the antidiabetic agent Dapagliflozin, featuring an acetyl group substituting a hydroxyl moiety on the glucoside ring. The compound retains the core sulfonamide-linked benzene-chloro-thiazole scaffold of the parent drug but exhibits altered physicochemical properties due to acetylation. This impurity arises during synthetic processes via acetylation of a secondary hydroxyl group, leading to reduced polarity and distinct chromatographic behavior. It serves as a critical HPLC reference standard for quantifying process-related impurities in Dapagliflozin formulations.