Mono-POC Methyl Tenofovir

Mono-POC Methyl Tenofovir is a synthetic impurity derived from Tenofovir, characterized by a mono-phosphonate esterification at the cyclopropylmethyl moiety and a methyl substitution on the terminal phosphate group. Its structure incorporates a 9-(2-phosphonylmethoxypropyl)adenine scaffold with a single methyl ester linkage, distinguishing it from the parent compound’s bis-phosphonate configuration. This impurity arises during API synthesis via partial esterification of the phosphonate backbone, resulting in a stable, non-degradative byproduct. It serves as a critical HPLC reference standard for quantifying process-related impurities in Tenofovir alafenamide formulations.