ABC01541BL

Monochlorotriiodothyronine

Monochlorotriiodothyronine is a tyrosine-derived tetracyclic hormone analog featuring three iodine atoms and a single chlorine substituent on aromatic rings, alongside two phenolic hydroxyl groups and an amide linkage. Its structure corresponds to a halogenated thyronine derivative with altered iodination and chlorination patterns compared to the parent thyroid hormone. This compound arises as a synthetic byproduct during API manufacturing via electrophilic halogenation of precursor rings. Functions as an HPLC reference standard for quantifying process-related impurities in thyroid hormone APIs.

On Request
Molecular Formula C15H11ClI3NO4
Molecular Weight 685.4200
CAS Number 909279-46-5 โœ“ Verified
PubChem CID 71587860 โ†—
Purity N/A
Product Type API Impurity
Lead Time On Request
IUPAC Name (2S)-2-amino-3-[3-chloro-4-(4-hydroxy-3,5-diiodophenoxy)-5-iodophenyl]propanoic acid
Official Reference Standards
Std Catalog # Quantity Price
USP 1A03250 โ†— 25 mg USD 2500.00

๐Ÿ“ Synonyms

3-Monochlorotriiodothyronine 909279-46-5 3-Chloro-3',5,5'-triiodo-L-thyronine Levothyroxine Impurity 10 UNII-CPY747550R CPY747550R (2S)-2-amino-3-[3-chloro-4-(4-hydroxy-3,5-diiodophenoxy)-5-iodophenyl]propanoic acid (S)-2-Amino-3-(3-chloro-4-(4-hydroxy-3,5-diiodophenoxy)-5-iodophenyl) Alanine, 3-(3-chloro-4-(4-hydroxy-3,5-diiodophenoxy)-5-iodophenyl)-, L- Levothyroxine sodium impurity, monochlorotriiodothyronine- [USP]

๐Ÿ”ฌ Chemical Identifiers

C1=C(C=C(C(=C1Cl)OC2=CC(=C(C(=C2)I)O)I)I)C[C@@H](C(=O)O)N
InChI=1S/C15H11ClI3NO4/c16-8-1-6(3-12(20)15(22)23)2-11(19)14(8)24-7-4-9(17)13(21)10(18)5-7/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1
HWGVSMDUSKJICA-LBPRGKRZSA-N

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