ABC01372OR

monoPOC-Et-Tenofovir

MonoPOC-Et-Tenofovir is a phosphorylated ethyl ester derivative of tenofovir, featuring a substituted phosphate group linked to an ethyl chain at the terminal hydroxyl of the parent compound's cyclopropylmethyl moiety. The structure retains the core 9-(2-phosphonylmethoxypropyl)adenine scaffold but incorporates an ethyl esterification at the monophosphate site, altering its solubility and reactivity profiles. This impurity arises during synthetic processes involving esterification steps, forming via partial hydrolysis or side-reactions in API manufacturing. It serves as a critical HPLC reference standard for quantifying process-related impurities in tenofovir drug substance batches.

On Request
Molecular Formula C16H26N5O7P
Molecular Weight 431.3800
CAS Number 1796539-92-8 ✓ Verified
PubChem CID 71750816 ↗
Purity N/A
Product Type API Impurity
Parent Drug Tenofovir
Lead Time On Request
IUPAC Name [[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-ethoxyphosphoryl]oxymethyl propan-2-yl carbonate

📝 Synonyms

1796539-92-8 (8R)-9-(6-Amino-9H-purin-9-yl)-5-ethoxy-8-methyl-2,4,7-trioxa-5-phosphanonanoic Acid Methyl 1-Methylethyl Ester 5-Oxide; Tenofovir Ethyl Monoisoproxil; [Isopropylcarbonyloxymethyl-(Ethoxy)-[(R)-9-(2-phosphonomethoxy)]propyl Adenine; Tenofovir disoproxil Impurity 100 CS-0164376 Tenofovir Disoproxil Impurity J; Mono-Poc Ethyl Tenofovir ((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(ethoxy)phosphoryl)oxy)methyl isopropyl carbonate? (Tenofovir Impurity pound(c) Tenofovir Monoisoproxil Ethoxy Impurity; ((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(ethoxy)phosphoryl)oxy)methyl isopropyl carbonate

🔬 Chemical Identifiers

CCOP(=O)(CO[C@H](C)CN1C=NC2=C(N=CN=C21)N)OCOC(=O)OC(C)C
InChI=1S/C16H26N5O7P/c1-5-26-29(23,27-9-24-16(22)28-11(2)3)10-25-12(4)6-21-8-20-13-14(17)18-7-19-15(13)21/h7-8,11-12H,5-6,9-10H2,1-4H3,(H2,17,18,19)/t12-,29?/m1/s1
JBEJTHIFJKPVQX-ICTCQJIBSA-N

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