N-Desmethyl Orphernadrine

N-Desmethyl Orphernadrine is an N-demethylated derivative of the tropane alkaloid Orphernadrine, characterized by a bicyclic tropane scaffold with a secondary amine at the nitrogen site. The compound retains the parent’s hydroxyl group and ester functionality but lacks the methyl substitution on the nitrogen atom, altering its lipophilicity and metabolic stability. Structurally, it features a 1-hydroxy-2-methylamino-3,4,5-trimethylcyclohexene ring system. This impurity arises as a synthetic byproduct during Orphernadrine API synthesis via N-demethylation pathways. It serves as an HPLC reference standard for quantifying N-desmethyl orphernadrine in Orphernadrine drug substance analysis.