Nicorandil Dimer Iodide

Nicorandil Dimer Iodide is a dimeric derivative formed via oxidative coupling of two nicorandil molecules, linked through their piperidinyl moieties with an intervening iodide-bridged nitroaromatic core. The structure retains the characteristic 5-nitro-2-propylpyridine scaffold of the parent drug, with symmetric substitution patterns and an iodide counterion stabilizing the dimeric framework. This impurity arises during synthetic oxidation steps or degradation pathways involving electrophilic iodide-mediated cross-linking. It serves as a critical HPLC reference standard for quantifying dimeric impurities in nicorandil drug substance batches.