Nicorandil Impurity 4 Dinitrate (Crude)

Nicorandil Impurity 4 Dinitrate (Crude) is a dinitrate derivative of Nicorandil, characterized by two nitrate ester groups (-ONO2) substituting the terminal nitroxy moiety of the parent compound. It retains the pyridine core and piperidinylmethyl side chain but exhibits oxidized nitrate functionality, forming a bis-ester structure. This impurity arises via oxidative degradation pathways, reflecting a loss of the nitroxy radical and incorporation of two nitrate esters. Its structural divergence from Nicorandil includes altered electron density and enhanced hydrophilicity due to the dinitrate groups. This crude form serves as a reference standard for HPLC-based impurity profiling in Nicorandil drug substance analysis.