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O-Fluoro Ezetimibe

O-Fluoro Ezetimibe is a fluorinated analog of Ezetimibe, featuring a 2-fluoro substitution at the tetrahydrofuran oxygen, replacing the native hydroxyl group. This structural modification introduces a fluoroether motif, while retaining the core phenolic hydroxyl and carboxylic acid ester functionalities. The compound arises as a synthetic byproduct during fluorinated derivative development. It serves as an HPLC reference standard for quantifying process-related impurities in Ezetimibe drug substance.

On Request
Molecular Formula C24H21F2NO3
Molecular Weight 409.4000
CAS Number 1798008-25-9 ✓ Verified
PubChem CID 125281874 ↗
Purity N/A
Product Type API Impurity
Parent Drug Ezetimibe
Lead Time On Request
IUPAC Name (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(2-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one
Other CAS Numbers (also listed on PubChem)
2743547-96-6
Official Reference Standards
Std Catalog # Quantity Price
USP 1A07340 ↗ 25 mg USD 1200.00

📝 Synonyms

1798008-25-9 2743547-96-6 Ezetimibe Fluoro Isomer 3'-(2-Fluorophenyl) ezetimibe (3R,4S)-1-(4-Fluorophenyl)-3-((S)-3-(2-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one (3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(2-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one (3R,4S)-1-(4-fluorophenyl)-3-[(3s)-3-(2-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone Ezetimibe o-Fluorobenzene Isomer Ezetimibe Impurity; (3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(2-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone; Ezetimibe Impurity Q

🔬 Chemical Identifiers

C1=CC=C(C(=C1)[C@H](CC[C@@H]2[C@H](N(C2=O)C3=CC=C(C=C3)F)C4=CC=C(C=C4)O)O)F
InChI=1S/C24H21F2NO3/c25-16-7-9-17(10-8-16)27-23(15-5-11-18(28)12-6-15)20(24(27)30)13-14-22(29)19-3-1-2-4-21(19)26/h1-12,20,22-23,28-29H,13-14H2/t20-,22+,23-/m1/s1
OBQFYRYCMDREFB-AKIFATBCSA-N

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