ABC00093QE

Olanzapine Impurity 13

Olanzapine Impurity 13 is a synthetic byproduct formed during the coupling reaction in olanzapine manufacturing, featuring a benzothiazole-piperazine hybrid structure with a thiophene-bridged dibenzazepine core. Its scaffold incorporates a 10-methylthio substitution and a 3-chloro-2-methylphenyl group, diverging from the parent drug by an additional sulfur-containing heterocycle. This impurity arises from side-chain oxidation under reductive amination conditions. It functions as an HPLC reference standard for quantifying process-related impurities in olanzapine bulk drug substance.

On Request
Molecular Formula C28H26N6S2
Molecular Weight 510.7000
CAS Number 1070876-09-3 โœ“ Verified
PubChem CID 138110402 โ†—
Purity 95%
Product Type API Impurity
Parent Drug Olanzapine
Lead Time 14 Days
IUPAC Name 1,4-Bis(2-methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-yl)piperazine

๐Ÿ“ Synonyms

1070876-09-3 4,4'-(1,4-Piperazinediyl)bis[2-methyl-10H-thieno[2,3-b][1,5]benzodiazepine] Olanzapine Impurity I CBW649E5J4 1,4-bis(2-methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-yl)piperazine 10H-Thieno[2,3-b][1,5]benzodiazepine, 4,4'-(1,4-piperazinediyl)bis[2-methyl- 4,4'-(1,4-Piperazinediyl)bis[2-methyl-10H-thieno[2,3-b][1,5]benzodiazepine] 10H-Thieno[2,3-b][1,5]benzodiazepine, 4,4'-(1,4-piperazinediyl)bis[2-methyl- 4,4'-(1,4-Piperazinediyl)bis[2-methyl-10H-thieno[2,3-b][1,5]benzodiazepine]

๐Ÿ”ฌ Chemical Identifiers

CC1=CC2=C(NC3=C(N=C2N2CCN(CC2)C=2C4=C(NC5=C(N2)C=CC=C5)SC(=C4)C)C=CC=C3)S1
InChI=1S/C28H26N6S2/c1-17-15-19-25(29-21-7-3-5-9-23(21)31-27(19)35-17)33-11-13-34(14-12-33)26-20-16-18(2)36-28(20)32-24-10-6-4-8-22(24)30-26/h3-10,15-16,31-32H,11-14H2,1-2H3
MLQMWTKHBAHDAN-UHFFFAOYSA-N

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