ABC01019CE

Olanzapine Lactam Impurity

Olanzapine Lactam Impurity is a structurally related synthetic byproduct arising from the cyclization of the piperidine side chain of Olanzapine, forming a five-membered lactam ring. This impurity retains the dibenzazepine core and methoxy substituent of the parent compound but features an amide linkage between the terminal nitrogen and alpha-carboxylic acid moiety. Its formation occurs via intramolecular amidation under specific synthetic conditions. This compound serves as a critical HPLC reference standard for impurity profiling in Olanzapine drug substance analysis.

On Request
Molecular Formula C17H20N4O2
Molecular Weight 312.3700
CAS Number 1017241-34-7 ✓ Verified
PubChem CID 136295210 ↗
Purity N/A
Product Type API Impurity
Parent Drug Olanzapine
Lead Time On Request
IUPAC Name 3-[(Z)-2-hydroxyprop-1-enyl]-4-(4-methylpiperazin-1-yl)-1,5-benzodiazepin-2-one
Official Reference Standards
Std Catalog # Quantity Price
USP 1A01010 ↗ 25 mg USD 1352.00

📝 Synonyms

1017241-34-7 Olanzapine Lactam Impurity Olanzapine ketolactam 3-[(Z)-2-Hydroxyprop-1-enyl]-4-(4-methylpiperazin-1-yl)-1,5-benzodiazepin-2-one (3Z)-1,3-Dihydro-4-(4-methyl-1-piperazinyl)-3-(2-oxopropylidene)-2H-1,5-benzodiazepin-2-one 2H-1,5-Benzodiazepin-2-one, 1,3-dihydro-4-(4-methyl-1-piperazinyl)-3-(2-oxopropylidene)-, (3Z)- (Z)-Olanzapine Ketolactam (Z)-4-(4-Methylpiperazin-1-yl)-3-(2-oxopropylidene)-1H-benzo[b][1,4]diazepin-2(3H)-one Olanzapin e lactam Impurity Olanzapine ketolactam impurity

🔬 Chemical Identifiers

C/C(=C/C1=C(N=C2C=CC=CC2=NC1=O)N3CCN(CC3)C)/O
InChI=1S/C17H20N4O2/c1-12(22)11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)23/h3-6,11,22H,7-10H2,1-2H3/b12-11-
CVKVZGLTQPNIEY-QXMHVHEDSA-N

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