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Olmesartan N2-Trityl Impurity

Olmesartan N2-Trityl Impurity is a synthetic byproduct arising from the tritylation of the N2-amino group in the olmesartan core structure. This impurity retains the tetracyclic scaffold of olmesartan but features a triphenylmethyl (trityl) moiety appended at the N2 position, substituting the native amine functionality. The compound exhibits a rigid aromatic framework with conjugated phenyl rings and a tetrazole-5-ylcarboxamide terminus, conferring enhanced hydrophobicity relative to the parent drug. It serves as a critical HPLC reference standard for quantifying tritylation-related impurities in olmesartan active pharmaceutical ingredient (API) batches.

On Request
Molecular Formula C43H40N6O3
Molecular Weight 688.8000
CAS Number 752179-89-8 ✓ Verified
PubChem CID 10699800 ↗
Purity N/A
Product Type API Impurity
Parent Drug Olmesartan
Lead Time On Request
IUPAC Name 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2-trityltetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid

📝 Synonyms

752179-89-8 N2-Trityl Olmesartan Acid 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(2-trityl-2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2-trityltetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid 1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-; 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid (N2-Tritylolmesartan) Olmesartan Impurity 71 SCHEMBL991977 4-(2-Hydroxy-2-propanyl)-2-propyl-1-{[2'-(2-trityl-2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-imidazole-5-carboxylic acid

🔬 Chemical Identifiers

CCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN(N=N4)C(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)C(=O)O)C(C)(C)O
InChI=1S/C43H40N6O3/c1-4-16-37-44-39(42(2,3)52)38(41(50)51)48(37)29-30-25-27-31(28-26-30)35-23-14-15-24-36(35)40-45-47-49(46-40)43(32-17-8-5-9-18-32,33-19-10-6-11-20-33)34-21-12-7-13-22-34/h5-15,17-28,52H,4,16,29H2,1-3H3,(H,50,51)
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