Paroxetine Related compound G

Paroxetine Related compound G is a synthetic byproduct arising from the alkylation step in Paroxetine production, characterized by a 4-(4-fluorophenyl)-1-piperidine core bearing a hydroxymethyl substituent at the α-position relative to the nitrogen, replacing the pyridine moiety of the parent drug. This impurity features a primary hydroxyl group and a fluorinated aromatic ring, conferring distinct chromatographic behavior. It functions as an HPLC reference standard for quantifying process-derived impurities in Paroxetine API batches.