ABC01105GJ

Pitavastatin S- isomer

Pitavastatin S-isomer is the enantiomerically pure stereoisomer of the HMG-CoA reductase inhibitor Pitavastatin, characterized by a 3-pyrroline core linked to a hydroxy-methylglutaryl moiety and a fluorinated tetrahydrofuran side chain. Its calcium-complexed structure (C50H46CaF2N2O8) features a lactone ring and two chiral centers, with the S-configuration at the key pyrroline stereocenter. This isomer is synthesized via stereoselective hydrogenation of a prochiral intermediate, diverging from the R-isomer through spatial arrangement of substituents. It serves as an HPLC reference standard for enantiomeric purity analysis in Pitavastatin API production.

On Request
Molecular Formula C50H46CaF2N2O8
Molecular Weight 881.0000
CAS Number 254452-88-5 ✓ Verified
PubChem CID 117587679 ↗
Purity N/A
Product Type API Impurity
Parent Drug Pitavastatin
Lead Time On Request
IUPAC Name calcium bis((E,3S,5R)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate)
Official Reference Standards
Std Catalog # Quantity Price
USP 1544745 ↗ 15 mg USD 1300.00

📝 Synonyms

254452-88-5 (3S,5R)-Pitavastatin Calcium Calcium (3S,5R,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate Pitavastatin (3S,5R)-Isomer Calcium Salt C50H46CaF2N2O8 ent-NK-104; Pitavastatin 3S,5R-Isomer Calcium Salt Pitavastatin calcium Impurity 3 SCHEMBL30516200 DTXSID501362232 Pitavastatin 3S,5R isomer calcium

🔬 Chemical Identifiers

C1C(C1)C2=NC3=CC=CC=C3C(=C2/C=C/[C@H](O)C[C@H](O)CC(=O)[O-])C4=CC=C(C=C4)F.C1C(C1)C2=NC3=CC=CC=C3C(=C2/C=C/[C@H](O)C[C@H](O)CC(=O)[O-])C4=CC=C(C=C4)F.[Ca+2]
InChI=1S/2C25H24FNO4.Ca/c2*26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31;/h2*1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31);/q;;+2/p-2/b2*12-11+;/t2*18-,19-;/m00./s1
RHGYHLPFVJEAOC-DHYXZBNNSA-L

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