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Prednisolone 21-formate

Prednisolone 21-formate is a corticosteroid derivative featuring a formate ester substitution at the C21 hydroxyl position of the parent compound, prednisolone. The molecule retains the characteristic oxidized A-ring (ฮ”ยน(ยฒ) double bond), 11ฮฒ-hydroxyl, and 17ฮฑ-hydroxyl functionalities. The 21-formate ester introduces a labile acyloxy group, rendering it a potential synthetic byproduct during esterification processes or a degradation product under acidic conditions. This compound serves as an HPLC reference standard for quantifying 21-ester-related impurities in prednisolone API batches.

On Request
Molecular Formula C22H28O6
Molecular Weight 388.5000
CAS Number 2141-22-2 โœ“ Verified
PubChem CID 88233443 โ†—
Purity N/A
Product Type API Impurity
Parent Drug Prednisolone
Lead Time On Request
IUPAC Name [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] formate

๐Ÿ“ Synonyms

Prednisolone 21-formate 2141-22-2 Prednisolone21-Formate EL8K5FJP3M SCHEMBL7996281 Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-, 21-formate Pregna-1,4-diene-3,20-dione, 21-(formyloxy)-11,17-dihydroxy-, (11beta)- [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] formate Pregna-1,4-diene-3,20-dione, 21-(formyloxy)-11,17-dihydroxy-, (11ss)- (9CI); Pregna-1,4-diene-3,20-dione, 11ss,17,21-trihydroxy-, 21-formate (6CI,7CI,8CI); Prednisolone 21-Formate

๐Ÿ”ฌ Chemical Identifiers

C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)COC=O)O)CCC4=CC(=O)C=C[C@]34C)O
InChI=1S/C22H28O6/c1-20-7-5-14(24)9-13(20)3-4-15-16-6-8-22(27,18(26)11-28-12-23)21(16,2)10-17(25)19(15)20/h5,7,9,12,15-17,19,25,27H,3-4,6,8,10-11H2,1-2H3/t15-,16-,17-,19+,20-,21-,22-/m0/s1
ZJZQOJKEOFRZMW-CWNVBEKCSA-N

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