Prothioconazole-3- hydroxy-desthio HCl

Prothioconazole-3-hydroxy-desthio HCl is a structurally modified analog of the triazole fungicide prothioconazole, featuring a hydroxyl group at the C3 position of the isothiazole ring and a desulfurized (desthio) substitution in the dithiocarbamate moiety. The compound retains the core 1,2,4-triazole and phenyl substituents of the parent drug but incorporates an additional hydroxyl functionality, altering its polarity and metabolic stability. This impurity arises via oxidative degradation pathways, specifically hydroxylation and sulfur oxidation. It serves as a critical HPLC reference standard for quantifying degradation byproducts in prothioconazole formulations.