Prothioconazole-alpha-hydroxy-desthio HCl salt (Crude)

Prothioconazole-alpha-hydroxy-desthio HCl salt (Crude) is a triazole-based impurity derived from the antifungal parent compound prothioconazole, characterized by the replacement of the sulfur atom in the prothioconazole core with a hydroxyl group at the alpha position of the terminal methyl group. This structural modification introduces a hydroxyl functionality while retaining the triazole and dimethylamine moieties, resulting in a desulfurized analog. The hydrochloride salt formation occurs via protonation of the tertiary amine, enhancing solubility. This impurity arises during synthetic pathways due to oxidative cleavage of the sulfur moiety. It serves as a critical HPLC reference standard for quantifying process-related impurities in prothioconazole formulations.