R-Amlodipine

(R)-Amlodipine is the enantiomerically pure stereoisomer of the calcium channel blocker amlodipine, characterized by the (R)-configuration at the chiral center of the 1,4-dihydropyridine core. Its structure features a 2-methyl-5-(2-aminoethoxy)-4-(2-chlorophenyl) substituent system, with the dihydropyridine ring adopting a cis-diaxial orientation. The compound exhibits distinct chiral discrimination in pharmacokinetic profiles compared to its S-enantiomer. This impurity arises during enantioselective synthesis or racemic resolution processes and serves as a critical chiral HPLC reference standard for enantiomeric purity determination in amlodipine active pharmaceutical ingredient (API) batches.