(R)-(-)-Ketoprofen

(R)-(-)-Ketoprofen is the enantiomerically pure (R)-configuration of the nonsteroidal anti-inflammatory drug Ketoprofen, featuring a chiral alpha-methylbenzeneacetic acid core substituted with a propyl group at the 3-position. This enantiomer exhibits distinct pharmacological activity compared to its (S)-counterpart, arising from the spatial arrangement of the aromatic ring and carboxylic acid moiety. As the active enantiomer in the racemic parent drug, it serves as a critical reference standard for enantiomeric purity analysis in chiral HPLC methods, ensuring compliance with ICH Q6A specifications for API impurity profiling.