(R)-Lercanidipine Hydrochloride

(R)-Lercanidipine Hydrochloride is the enantiomerically pure hydrochloride salt of the calcium channel blocker lercanidipine. It retains the dihydropyridine core with a 2-(4-chlorophenyl)-1-methylethyl substituent at position 4, an ester-linked phenethyl group at position 3, and a 3-phenylpropionyl moiety at position 2. The (R) configuration at the chiral center confers distinct stereochemical properties compared to the parent drug's racemic form, while the hydrochloride salt enhances crystallinity and solubility. This compound arises as a synthetic byproduct during enantioselective API synthesis and functions as an HPLC reference standard for enantiomeric purity analysis in pharmaceutical quality control.