(R,R)- Empagliflozin impurity

(R,R)- Empagliflozin impurity is a diastereomeric byproduct arising from asymmetric synthesis of the SGLT2 inhibitor empagliflozin. It retains the core benzene-pyran-sulfonamide scaffold but exhibits inverted stereochemistry at the 4,5-dihydroxytetrahydrofuran ring junction, resulting in distinct chiral configurations at C-4 and C-5. This structural divergence creates a non-superimposable mirror image of the parent compound’s pharmacophore, leading to differential interaction with chiral chromatographic phases. Serves as a chiral HPLC reference standard for quantifying enantiomeric purity in empagliflozin API batches.