Rabeprazole Impurity G Sulfone is a degradation byproduct arising from oxidative modification of the sulfinyl moiety in the parent drug's pyridylmethylsulfinyl side chain, resulting in a sulfone functional group. This impurity retains the benzimidazole core and 4-methyl substitution characteristic of rabeprazole but features an oxidized sulfonyl bridge connecting the pyridine ring. Its structural stability and distinct polarity enable differentiation via HPLC, serving as a reference standard for quantifying oxidative degradation pathways in rabeprazole formulations.
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