Rifamycin-SV

Rifamycin-SV is a semi-synthetic macrocyclic lactam derivative characterized by a 21-membered polyene ring system substituted with hydroxy, methoxy, and acylamino functionalities. It exhibits structural homology to Rifamycin B but features a 3'-hydroxyl group and a 5'-methyl ester, distinguishing it as a key intermediate in the biosynthetic pathway of rifamycin antibiotics. The molecule contains conjugated ketone moieties and a terminal carboxylic acid, contributing to its antibiotic activity. It serves as an HPLC reference standard for quantifying process-related impurities in rifampicin formulations.