ABC01218DH

Ritonavir Impurity N

Ritonavir Impurity N is a structurally related isomer arising from synthetic divergence during the formation of the naphthalene-thiazole core. It retains the parent drug's bicyclic scaffold but features an alternative substitution pattern on the naphthalene ring, incorporating a 2-aminothiazole moiety linked via a methylene bridge to a cyclohexylmethyl side chain. The compound contains multiple hydrogen bond donors/acceptors, including amide and sulfonamide functionalities, which influence its chromatographic behavior. This impurity serves as a critical HPLC reference standard for quantifying process-related variability in ritonavir formulations.

On Request
Molecular Formula C37H48N6O5S2
Molecular Weight 720.9000
CAS Number 202816-62-4 ✓ Verified
PubChem CID 515815 ↗
Purity N/A
Product Type API Impurity
Parent Drug Ritonavir
Lead Time On Request
IUPAC Name 1,3-thiazol-5-ylmethyl N-[(2S,4S,5S)-4-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate

📝 Synonyms

4-Dehydroxy-5-hydroxy Ritonavir 202816-62-4 Ritonavir 4-hydroxy isomer UNII-QA8V47KHDS QA8V47KHDS Ritonavir impurity N [EP] DTXSID40174138 2,7,10,12-Tetraazatridecanoic acid, 5-hydroxy-12-methyl-9-(1-methylethyl)-13-(2-(1-methylethyl)-4-thiazolyl)-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3S,5S,6S,9S)- Thiazol-5-ylmethyl ((1S,3S,4S)-1-benzyl-3-hydroxy-4-(((2S)-3-methyl-2-((methyl((2-(1-methylethyl)thiazol-4-yl)methyl)carbamoyl)amino)butanoyl)amino)-5-phenylpentyl)carbamate Thiazol-5-ylmethyl (2S,4S,5S)-4-hydroxy-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido(-3-methylbutanamido)-1,6-diphenylhexan-2-ylcarbamate

🔬 Chemical Identifiers

CC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CC=CC=C2)[C@H](C[C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O
InChI=1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(39-29)25(3)4)34(45)41-31(17-27-14-10-7-11-15-27)32(44)18-28(16-26-12-8-6-9-13-26)40-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,40,47)(H,41,45)(H,42,46)/t28-,31-,32-,33-/m0/s1
VRNXMJYSOAQBMK-XGKFQTDJSA-N

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