ABC01215DN

Ritonavir N acetyl impurity (Imp C)

Ritonavir N acetyl impurity (Imp C) is a structurally related degradation byproduct derived from the acetylation of a primary amine in the Ritonavir scaffold. It features a substituted cyclohexane core with a sulfonamide moiety and an N-acetylated secondary amine, distinguishing it from the parent compound by the presence of an acetyl group at the nitrogen of the terminal piperazine ring. This impurity arises during synthetic processes due to side-chain acetylation under specific reaction conditions. Its precise application lies as a reference standard for HPLC-based quantification of process-related impurities in Ritonavir drug substance analysis.

On Request
Molecular Formula C25H29N3O4S
Molecular Weight 467.6000
CAS Number 1010808-43-1 ✓ Verified
PubChem CID 71752515 ↗
Purity N/A
Product Type API Impurity
Parent Drug Ritonavir
Lead Time On Request
IUPAC Name 1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-5-acetamido-3-hydroxy-1,6-diphenylhexan-2-yl]carbamate

📝 Synonyms

1010808-43-1 Ritonavir impurity C [EP] 1,3-Thiazol-5-ylmethyl N-[(1S,2S,4S)-4-(acetylamino)-1-benzyl-2-hydroxy-5-phenylpentyl]carbamate Thiazol-5-ylmethyl ((1S,2S,4S)-4-(acetylamino)-1-benzyl-2-hydroxy-5-phenylpentyl)carbamate UNII-8KV2H7R99M 8KV2H7R99M DTXSID60143725 1,3-Thiazol-5-ylmethyl N-((1S,2S,4S)-4-(acetylamino)-1-benzyl-2-hydroxy-5-phenylpentyl)carbamate Carbamic acid, N-((1S,2S,4S)-4-(acetylamino)-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl)-, 5-thiazolylmethyl ester RITONAVIR IMPURITY C [EP IMPURITY]

🔬 Chemical Identifiers

CC(=O)N[C@@H](CC1=CC=CC=C1)C[C@@H]([C@H](CC2=CC=CC=C2)NC(=O)OCC3=CN=CS3)O
InChI=1S/C25H29N3O4S/c1-18(29)27-21(12-19-8-4-2-5-9-19)14-24(30)23(13-20-10-6-3-7-11-20)28-25(31)32-16-22-15-26-17-33-22/h2-11,15,17,21,23-24,30H,12-14,16H2,1H3,(H,27,29)(H,28,31)/t21-,23-,24-/m0/s1
LGKRKMCCXYIVTI-XWGVYQGASA-N

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