Rivaroxyban- Des chloro impurity

Rivaroxyban-Des chloro impurity is a structurally related degradation byproduct of Empagliflozin, characterized by the absence of a chloro substituent at the benzene ring and retention of a sulfonamide moiety linked to a pyridine core. Its molecular architecture includes a substituted phenyl ring conjugated to a piperazine-derived amide, with an ether bridge connecting to the sulfonamide functionality. This impurity arises during synthetic pathways due to partial dechlorination, resulting in altered electronic properties compared to the parent drug. It serves as a critical HPLC reference standard for quantifying process-related impurities in Empagliflozin active pharmaceutical ingredient (API) batches.