Rivaroxyban- R- isomer

Rivaroxyban-R-isomer is the enantiomeric counterpart of the anticoagulant Rivaroxaban, featuring a chiral center at the pyrazole-fused tetrahydrothiazole core. Its structure incorporates a benzylsulfonamide moiety, a 5-chlorophenyl ring, and a pyrazole-linked tetrahydrothiazole with R-configuration. This impurity arises from partial enantioselective synthesis or racemization during Rivaroxaban production. The compound retains the parent drug’s key pharmacophoric elements but exhibits distinct stereochemical interactions. It serves as a critical reference standard for chiral HPLC method validation in API purity profiling.