Rosuvastatin 5-Keto acid impurity is a degradation byproduct arising from oxidative cleavage of the parent statin's 5-hydroxy group, yielding a ketone functionality at the C5 position coupled with a carboxylic acid moiety. This impurity retains the core sulfone bridge and fluorinated phenyl ring characteristic of Rosuvastatin but features an oxidized pyridine substituent. The compound serves as a critical HPLC reference standard for quantifying oxidative degradation pathways in Rosuvastatin formulations.
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