ABC01255XO

Salmeterol Impurity G

Salmeterol Impurity G is a synthetic byproduct formed during the alkylation step of salmeterol synthesis, characterized by a bis-alkylated aromatic scaffold with a terminal hydroxyl group and a side-chain tertiary amine. Its structure features a para-coupled benzene ring system with an ether-linked hydroxyethyl substituent, differing from the parent compound by an additional methylene bridge in the side chain. This impurity exhibits enhanced hydrophobicity due to extended aliphatic linkage, leading to distinct HPLC retention profiles. It functions as a reference standard for monitoring alkylation efficiency in salmeterol API manufacturing.

On Request
Molecular Formula C50H72N2O7
Molecular Weight 813.1000
CAS Number 1391051-88-9 ✓ Verified
PubChem CID 71752151 ↗
Purity N/A
Product Type API Impurity
Parent Drug Salmeterol
Lead Time On Request
IUPAC Name 2-[[[2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl]-[6-(4-phenylbutoxy)hexyl]amino]methyl]-5-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol

📝 Synonyms

Salmeterol EP Impurity G 1391051-88-9 2-[[[2-Hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl]-[6-(4-phenylbutoxy)hexyl]amino]methyl]-5-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol 4-(1-Hydroxy-2-((2-hydroxy-4-(1-hydroxy-2-((6-(4-phenylbutoxy)hexyl)amino)ethyl)benzyl)(6-(4-phenylbutoxy)hexyl)amino)ethyl)-2-(hydroxymethyl)phenol SalmeterolEP Impurity G/ Salmeterol N-Alkyl Impurity (Salmeterol Dimer Impurity) Salmeterol Impurity 20 C50H72N2O7 MFCD29918780 AKOS027327317 FS178211

🔬 Chemical Identifiers

C1=CC=C(C=C1)CCCCOCCCCCCNCC(C2=CC(=C(C=C2)CN(CCCCCCOCCCCC3=CC=CC=C3)CC(C4=CC(=C(C=C4)O)CO)O)O)O
InChI=1S/C50H72N2O7/c53-40-46-35-43(27-28-47(46)54)50(57)39-52(30-14-2-4-16-32-59-34-18-12-24-42-21-9-6-10-22-42)38-45-26-25-44(36-48(45)55)49(56)37-51-29-13-1-3-15-31-58-33-17-11-23-41-19-7-5-8-20-41/h5-10,19-22,25-28,35-36,49-51,53-57H,1-4,11-18,23-24,29-34,37-40H2
DJQSLAMRWZOBFB-UHFFFAOYSA-N

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