saxagliptin diketo impurity

Saxagliptin diketo impurity is a structurally related degradation product formed via oxidative cleavage of the propyl side chain adjacent to the pyrazine ring of saxagliptin. It features a substituted pyrazine core linked to a sulfonamide moiety and a terminal diketone functional group, resulting from the oxidation of the hydroxyl-bearing methylene unit. This impurity arises under forced degradation conditions and serves as a critical HPLC reference standard for quantifying oxidative degradation pathways in saxagliptin formulations.