Silodosin glucuronide is a Phase II metabolite of the ฮฑ1-adrenergic antagonist Silodosin, formed via glucuronidation of the parent compound's tertiary amine. The structure features a dibenzazepine scaffold conjugated to a ฮฒ-D-glucuronic acid moiety through an N-glycosidic linkage, introducing a carboxylic ester and multiple hydroxyl groups. This conjugation enhances water solubility while retaining the core pharmacophore. The compound serves as an HPLC reference standard for quantifying Silodosin-related impurities in pharmaceutical formulations.
