ABC01287ML

Simvastatin Acid Ammonium Salt

Simvastatin Acid Ammonium Salt is the deprotonated carboxylic acid derivative of simvastatin, featuring a hydroxyl group at the terminal ฮณ-lactone ring and an ammonium counterion (NH4+) paired with the conjugate base of the acid. The compound retains the core mevinolinic structure of simvastatin, including the 1-pyrroline moiety and a methyl-substituted lactone ring, but exhibits a fully ionized carboxylate group due to ammonium salt formation. This species arises as a synthetic byproduct during API synthesis or as a degradation product under alkaline conditions. It serves as a reference standard for HPLC-based impurity profiling in simvastatin formulations.

On Request
Molecular Formula C25H43NO6
Molecular Weight 453.6000
CAS Number 139893-43-9 โœ“ Verified
PubChem CID 10961424 โ†—
Purity N/A
Product Type API Impurity
Parent Drug Simvastatin
Lead Time On Request
IUPAC Name azanium (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate
Official Reference Standards
Std Catalog # Quantity Price
USP 1A08000 โ†— 25 mg USD 975.00

๐Ÿ“ Synonyms

Simvastatin ammonium salt 139893-43-9 Tenivastatin ammonium UNII-76RD797JAX 76RD797JAX Ammonium simvastatin EC 604-165-5 Simvastatin Carboxylic Acid Ammonium Salt DTXSID60449890 RefChem:183135

๐Ÿ”ฌ Chemical Identifiers

CCC(C)(C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@H](C[C@H](CC(=O)[O-])O)O)C.[NH4+]
InChI=1S/C25H40O6.H3N/c1-6-25(4,5)24(30)31-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-18(26)13-19(27)14-22(28)29;/h7-8,11,15-16,18-21,23,26-27H,6,9-10,12-14H2,1-5H3,(H,28,29);1H3/t15-,16-,18+,19+,20-,21-,23-;/m0./s1
FFPDWNBTEIXJJF-OKDJMAGBSA-N

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