sofosbuvir dibenzoyl lactone

Sofosbuvir dibenzoyl lactone is a synthetic byproduct arising from the acylation of a hydroxyl group in the sofosbuvir precursor, featuring a cyclic ester (lactone) core substituted with two benzoyl moieties and a fluorinated phenyl ring. Its structure incorporates conjugated aromatic systems, ester linkages, and a γ-lactone ring, differing from the parent drug by the absence of the uracil moiety and the presence of benzoylated side chains. This compound serves as an HPLC reference standard for quantifying process-related impurities in sofosbuvir active pharmaceutical ingredient synthesis.