Sugammadex sulfoxide Impurity-1

Sugammadex sulfoxide Impurity-1 is a structurally related degradation byproduct of Sugammadex, characterized by a sulfoxide functional group (RSOR) formed via oxidative modification of a sulfide moiety in the parent cyclodextrin-based gamma-butyrolactone scaffold. This impurity retains the core trisubstituted gamma-cyclodextrin framework with glycosidic linkages and hydroxyl substituents but exhibits altered stereochemistry at the sulfur center. The sulfoxide oxidation state introduces a chiral sulfoxide stereocenter, differentiating it from the parent compound's sulfide configuration. This impurity serves as a critical HPLC reference standard for quantifying oxidative degradation pathways in Sugammadex formulations.